AustralieFrV1, Main, Exploration, bibRecord, 005988

Pregnancy outcomes in pulmonary arterial hypertension in the modern management era

Identifieur interne : 005988 ( Main/Exploration ); précédent : 005987; suivant : 005989

Pregnancy outcomes in pulmonary arterial hypertension in the modern management era

Auteurs : Xavier Jaïs [France] ; Karen M. Olsson [Allemagne] ; Joan A. Barbera [Espagne] ; Isabel Blanco [Espagne] ; Adam Torbicki [Pologne] ; Andrew Peacock [Royaume-Uni] ; C. Dario Vizza [Italie] ; Peter Macdonald [Australie] ; Marc Humbert [France] ; Marius M. Hoeper [Allemagne]

Source :

The European respiratory journal [ 0903-1936 ] ; 2012.

RBID : Pascal:12-0381526

Descripteurs français

Pascal (Inist)
- Hypertension artérielle pulmonaire, Hypertension artérielle, Insuffisance cardiaque, Gestation, Pronostic, Artère, Poumon, Coeur droit, Pneumologie.

English descriptors

KwdEn :
- Artery, Heart failure, Hypertension, Lung, Pneumology, Pregnancy, Prognosis, Pulmonary hypertension, Right heart.

Abstract

Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years. We compiled a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH. During a 3-yr period, the 13 participating centres reported 26 pregnancies. Three (12%) females died and one (4%) developed right heart failure requiring urgent heart-lung transplantation. There were eight abortions; two spontaneous and six induced. 16 (62%) pregnancies were successful, i.e. the females delivered healthy babies without complications. These females had well controlled PAH (pulmonary vascular resistance (PVR) 500±352 dyn.s.cm^-5); eight of them were long-term responders to calcium channel blockers. In contrast, the females who died or required transplantation had poorly controlled PAH (PVR 1,667±209 dyn.s.cm^-5). Pregnancy remains associated with a substantial mortality rate in PAH. However, our results indicate that the outcome of pregnancy in PAH has improved, at least when PAH is well controlled, and particularly in long-term responders to calcium channel blockers. These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered.

Affiliations:

Allemagne, Australie, Espagne, France, Italie, Pologne, Royaume-Uni
Basse-Saxe, Latium, Nouvelle-Galles du Sud, Écosse
Glasgow, Hanovre, Rome, Sydney
Université de Glasgow

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Artery</term>
<term>Heart failure</term>
<term>Hypertension</term>
<term>Lung</term>
<term>Pneumology</term>
<term>Pregnancy</term>
<term>Prognosis</term>
<term>Pulmonary hypertension</term>
<term>Right heart</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hypertension artérielle pulmonaire</term>
<term>Hypertension artérielle</term>
<term>Insuffisance cardiaque</term>
<term>Gestation</term>
<term>Pronostic</term>
<term>Artère</term>
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<front><div type="abstract" xml:lang="en">Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years. We compiled a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH. During a 3-yr period, the 13 participating centres reported 26 pregnancies. Three (12%) females died and one (4%) developed right heart failure requiring urgent heart-lung transplantation. There were eight abortions; two spontaneous and six induced. 16 (62%) pregnancies were successful, i.e. the females delivered healthy babies without complications. These females had well controlled PAH (pulmonary vascular resistance (PVR) 500±352 dyn.s.cm<sup>-5</sup>
); eight of them were long-term responders to calcium channel blockers. In contrast, the females who died or required transplantation had poorly controlled PAH (PVR 1,667±209 dyn.s.cm<sup>-5</sup>
). Pregnancy remains associated with a substantial mortality rate in PAH. However, our results indicate that the outcome of pregnancy in PAH has improved, at least when PAH is well controlled, and particularly in long-term responders to calcium channel blockers. These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered.</div>
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<country name="Italie"><region name="Latium"><name sortKey="Dario Vizza, C" sort="Dario Vizza, C" uniqKey="Dario Vizza C" first="C." last="Dario Vizza">C. Dario Vizza</name>
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<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Macdonald, Peter" sort="Macdonald, Peter" uniqKey="Macdonald P" first="Peter" last="Macdonald">Peter Macdonald</name>
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   |texte=   Pregnancy outcomes in pulmonary arterial hypertension in the modern management era
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Pregnancy outcomes in pulmonary arterial hypertension in the modern management era

Pregnancy outcomes in pulmonary arterial hypertension in the modern management era

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